| 名称
|
Β-Amyloid (1-28)
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| 别名
|
Abeta 1-28
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| 序列（单字母缩写）
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DAEFRHDSGYEVHHQKLVFFAEDVGSNK
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| 序列（三字母缩写）
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{ASP}{ALA}{GLU}{PHE}{ARG}{HIS}{ASP}{SER}{GLY}{TYR}{GLU}{VAL}{HIS}{HIS}{GLN}{LYS}{LEU}{VAL}{PHE}{PHE}{ALA}{GLU}{ASP}{VAL}{GLY}{SER}{ASN}{LYS}
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| 基本描述
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Beta amyloid is an extracellular filamentous protein deposit found in the brain. It is the major protein component of amyloid cores and neuritic plaques and is also found as a deposit in neurofibrillary tangles. Beta-amyloid peptide (Abeta), the major constituent of amyloid plaques in the brains of Alzheimer’s patients, is thought to be the cause of Alzheimer’s Disease (AD). Beta-amyloid peptide is generated from the beta-amyloid precursor protein (beta APP) in a two-step process.
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| 溶解度
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Soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents.
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| 分子量
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3262.500
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| 化学式
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C145H209N41O46
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| 纯度
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> 95%
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| 存储条件
|
Store at -20°C.
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| 注释
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Forms fibrils that have the same antigenic and structural features as the native Alzheimer Disease Amyloid filaments.
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| Documents
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| Figures
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| Reference
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Gorbita CH. The structure of nanotubes formed by diphenylalanine, the core recognition motif of Alzheimer's beta-amyloid polypeptide. Chem. Commun(Camb). Jun 2006; 14(22): 2332-2334.
Song Y, et al. Comparison of MR images and histochemical localization of intra-arterially administered microglia surrounding beta-amyloid deposits in the rat brain. Histol. Histopathol. Jul 2006; 21(7): 705-711.
Park HY, et al. Modulation of neutrophil apoptosis by beta-amyloid proteins. Int. Immunopharmacol. Jul 2006; 6(7): 1061-1069.
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Β-Amyloid (1-28)
