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服务
产品  
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 PACAP (6-38), Human, Ovine, Rat
| 名称
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PACAP (6-38), Human, Ovine, Rat
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| 别名
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| 序列（单字母缩写）
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FTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNK-NH2
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| 序列（三字母缩写）
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{PHE}{THR}{ASP}{SER}{TYR}{SER}{ARG}{TYR}{ARG}{LYS}{GLN}{MET}{ALA}{VAL}{LYS}{LYS}{TYR}{LEU}{ALA}{ALA}{VAL}{LEU}{GLY}{LYS}{ARG}{TYR}{LYS}{GLN}{ARG}{VAL}{LYS}{ASN}{LYS}-NH2
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| C-端
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NH2
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| 基本描述
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PACAP (6-38) is a potent antagonist of PACAP 38. PACAP (6-38) is much more potent and selective than PACAP (6-27) in the inhibition of PACAP-27-stimulated pituitary adenylate cyclase. Ki values for the inhibition of the enzyme were 7nM and 150 nM, respectively. PACAP (6-38) caused a small but significant (approximately 20%) inhibition of the NANC relaxation due to electrical field stimulation (1 Hz or 10 Hz for 20 s). At these frequencies PACAP (6-38) caused no inhibition of the NANC relaxation in the presence of the P2 purinoceptor antagonist pyridoxal-phosphate-6-azophenyl-2',4'-disulphonic acid (or PPADS) plus the NO-synthase blocker NG-nitro-L-arginine; in preparations pretreated with L-NOARG alone, PACAP (6-38) retained its inhibitory effect.
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| 溶解度
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Soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weigh out a smaller portion of the contents.
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| 分子量
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4024.760
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| 化学式
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C182H300N56O45S1
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| 纯度
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> 95%
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| 存储条件
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Store the peptide at -20°C.
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| 注释
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This peptide is a potent agonist.
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