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服务
产品  
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Neurokinin A (4-10)
| 名称
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Neurokinin A (4-10)
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| 别名
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NKA (4-10)
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| 序列（单字母缩写）
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DSFVGLM-NH2
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| 序列（三字母缩写）
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{ASP}{SER}{PHE}{VAL}{GLY}{LEU}{MET}-NH2
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| C-端
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NH2
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| 基本描述
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A structure-activity study of the neurokinin A (NKA) fragment NKA(4-10) was performed to investigate the importance of amino acid residues for receptor efficacy, potency and affinity at the NK2 receptor in human colon circular muscle. Two series of NKA(4-10) analogues were produced with either L-alanine or the D-enantiomer substituted. Their activities were determined in vitro by means of radioligand binding and isolated smooth muscle pharmacology.
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| 分子量
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766.900
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| 化学式
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C34H54N8O10S
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| 纯度
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> 95%
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| 存储条件
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Store at -20°C.
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| 注释
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| Documents
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| Figures
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| Reference
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Lynn P, et al. Mechanical activation of rectal intraganglionic laminar endings in the guinea pig distal gut. J. Physiol. Apr 2005; 564(Pt 2): 589-601.
Myers AC, et al. A novel role for tachykinin neurokinin-3 receptors in regulation of human bronchial Ganglia neurons. Am. J. Respir. Crit. Care Med. Feb 2005; 171(3): 212-216.
Cao W, et al. NK2 receptor-mediated spontaneous phasic contractions in normal and ulcerative colitis human sigmoid colon. J. Pharmacol. Exp. Ther. Jun 2006; 317(3): 1349-1355.
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