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产品  
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Melittin
| 名称
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Melittin
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| 别名
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| 序列（单字母缩写）
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GIGAVLKVLTTGLPALISWIKRKRQQ-NH2
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| 序列（三字母缩写）
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{GLY}{ILE}{GLY}{ALA}{VAL}{LEU}{LYS}{VAL}{LEU}{THR}{THR}{GLY}{LEU}{PRO}{ALA}{LEU}{ILE}{SER}{TRP}{ILE}{LYS}{ARG}{LYS}{ARG}{GLN}{GLN}-NH2
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| C-端
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NH2
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| 基本描述
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This 26-residue polypeptide isolated from bee venom binds calmodulin in a Ca2+-dependent manner, activates phospholipase A2, and inhibits protein kinase C (IC50=5-7 mM) by binding to the catalytic domain in a Mg-ATP-sensitive manner.
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| 分子量
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2846.460
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| 化学式
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C131H229N39O31
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| 纯度
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> 95%
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| 存储条件
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Store at -20°C
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| 注释
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Polypeptide from honey bee venom
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| Documents
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| Figures
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| Reference
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Saugar JM, et al. Activity of cecropin A-melittin hybrid peptides against colistin-resistant clinical strains of Acinetobacter baumannii: molecular basis for the differential mechanisms of action. Antimicrob Agents Chemother. Apr 2006;50(4):1251-1256.
Loutet SA, et al. A complete lipopolysaccharide inner core oligosaccharide is required for resistance of Burkholderia cenocepacia to antimicrobial peptides and bacterial survival in vivo. J Bacteriol. Mar 2006;188(6):2073-2080.
Shank LP, et al. Redesigning channel-forming peptides: amino acid substitutions that enhance rates of supramolecular self-assembly and raise ion transport activity. Biophys J. Mar 15 2006;90(6):2138-2150.
NW Palm., etc. Role of the inflammasome in defense against venoms. Proc Natl Acad Sci U S A. 2013 Jan;110(5):1809-14.
Hood JL., etc. Cytolytic nanoparticles attenuate HIV-1 infectivity. Antivir Ther. 2012 Sep;18(1):95-103.
Tina Y. Liu., etc. Pnas Plus: Lipid Interaction Of The C Terminus And Association Of The Transmembrane Segments Facilitate Atlastin-Mediated Homotypic Endoplasmic Reticulum Fusion. Proc Natl Acad Sci U S A. 20
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