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服务
产品  
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Melanin Concentrating Hormone, Salmon
| 名称
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Melanin Concentrating Hormone, Salmon
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| 别名
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MCH
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| 序列（单字母缩写）
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DTMRCMVGRVYRPCWEV
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| 序列（三字母缩写）
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{ASP}{THR}{MET}{ARG}{CYS}{MET}{VAL}{GLY}{ARG}{VAL}{TYR}{ARG}{PRO}{CYS}{TRP}{GLU}{VAL}
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| 化学桥
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Disulfide bridge: Cys5-Cys14
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| 基本描述
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Melanin Concentrating Hormone (MCH), a 19 amino acid cyclic peptide, is largely expressed in the hypothalamus. Melanin Concentrating Hormone is implicated in the control of general arousal and goal-orientated behaviours in mammals, and appears to be a key messenger in the regulation of food intake. An understanding of the biological actions of Melanin Concentrating Hormone has been so far hampered by the lack of information about its receptor(s) and their location in the brain. We recently identified the orphan G-protein-coupled receptor SLC-1 as a receptor for the neuropeptide Melanin Concentrating Hormone.
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| 分子量
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2099.480
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| 化学式
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C89H139N27O24S4
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| 纯度
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> 95%
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| 存储条件
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Store at -20°C. Keep tightly closed. Store in a cool dry place.
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| 注释
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Melanin Concentrating Hormone (MCH) is hypothalamic appetite stimulant and the ligand for somatostatin-like receptor 1(SLC-1).
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| Documents
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| Reference
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Fry D, et al. Characterization of a neuronal cell line expressing native human melanin-concentrating hormone receptor 1 (MCHR1). Int. J. Biochem. Cell Biol. Aug 2006; 38(8): 1290-1299.
Wu WL, et al. Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists. Bioorg Med. Chem. Lett. Jul 2006; 16(14): 3674-3678.
Wu WL, et al. Synthesis and structure-activity relationships of piperidine-based melanin-concentrating hormone receptor 1 antagonists. Bioorg Med. Chem. Lett. Jul 2006; 16(14): 3668-3673.
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