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服务
产品  
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Apamin
| 名称
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Apamin
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| 别名
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| 序列（单字母缩写）
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CNCKAPETALCARRCQQH-NH2
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| 序列（三字母缩写）
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{CYS}{ASN}{CYS}{LYS}{ALA}{PRO}{GLU}{THR}{ALA}{LEU}{CYS}{ALA}{ARG}{ARG}{CYS}{GLN}{GLN}{HIS}-NH2
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| C-端
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NH2
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| 化学桥
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Disulfide Bridge Cys1-Cys11 and Cys3-Cys15
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| 基本描述
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Apamin, a bee venom polypeptide, blocks specifically the Ca2+-dependent K+ channels that are not blocked by tetraethylammonium chloride in muscle cells. Apamin is a ly specific compound that tightly binds to the Ca2+ slow channels, thus blocking the slow APs in heart muscle. In addition, quinidine antagonizes the apamin binding on the slow APs.
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| 分子量
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2027.300
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| 化学式
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C79H131N31O24S4
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| 纯度
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> 95%
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| 存储条件
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Store at -20°C. Keep tightly closed. Store in a cool dry place.
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| 注释
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Originally isolated from Apis mellifera. A small conductance Ca2+-activated K+ channel blocker.
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| Documents
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| Figures
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| Reference
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Kato M, et al. SK Channel Blocker Apamin Inhibits Slow Afterhyperpolarization Currents in Rat Gonadotropin-Releasing Hormone Neurones. J. Physiol. 2006 Apr.
Deschaux O, Bizot JC. Apamin produces selective improvements of learning in rats. Neurosci. Lett. Sep 2005; 386(1): 5-8.
Mpari B, et al. Differential effects of two blockers of small conductance Ca2+-activated K+ channels, apamin and lei-Dab7, on learning and memory in rats. J. Integr. Neurosci. Sep 2005; 4(3): 381-396.
Dana V. Skarra., etc. CyPPA, a positive modulator of small-conductance Ca2+-activated K+ channels, inhibits phasic uterine contractions and delays preterm birth in mice. Am J Physiol Cell Physio
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