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服务
产品  
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Rabbit Anti-APOE Antibody/载脂蛋白E抗体
| 名称
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Rabbit Anti-APOE Antibody
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| 中文名
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载脂蛋白E抗体
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| 基本描述
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Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Compared with E3 and E4, E2 exhibits the lower receptor binding affinity. Defects in ApoE are a cause of hyperlipoproteinemia type III due to increased plasma cholesterol and triglycerides levels which are the consequence of impaired clearance of chylomicron and VLDL remnants.
Summary: Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
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| 抗体类型
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兔多抗
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| 免疫原
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偶联多肽或重组蛋白
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| 浓度
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1mg/ml
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| 存储条件
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Store at -20°C.
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| 亚型
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IgG
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| 成分
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亲和纯化，0.01M PBS(pH7.4)，1% BSA
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| 应用
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IH(P)免疫组化(石蜡、冰冻)；IC细胞免疫化学；WB免疫印迹等
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