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服务
产品  
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Rabbit Anti-ART4 Antibody>/二磷酸腺苷核糖基转移酶4抗体
| 名称
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Rabbit Anti-A4GALT Antibody
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| 中文名
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α1,4-半乳糖基转移酶1
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| 基本描述
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Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins.Expression of CD77, also called Gb3, sensitizes a cell to verotoxins, causing cellular injury that can lead to disease. Therefore, the complex regulation of CD77 biosynthesis and the activity of the enzymes involved, such as CD77 synthase, can be studied by compared gene expression between toxin-sensitive and insensitive tissues and cell lines. The tissue expression of CD77 synthase occurs in the kidney, mesenteric lymph node, spleen, and brain. Burkitt leukemia cells express very levels of CD77 as well as CD77 synthase, and are sensitive to verotoxin induced apoptosis. These megakaryoblasts then never mature, to the arrest of platelet generation in the bone marrow, which may cause thrombocytopenia, a symptom associated with various hemorrhagic conditions.
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| 抗体类型
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兔多抗
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| 免疫原
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偶联多肽或重组蛋白
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| 浓度
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1mg/ml
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| 存储条件
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Store at -20°C.
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| 亚型
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IgG
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| 成分
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亲和纯化，0.01M PBS(pH7.4)，1% BSA
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| 应用
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WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500
IF=1:100-500
optimal dilutions/concentrations should be determined by the end user.
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