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服务
产品  
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Mouse Anti-Uromucoid Antibody/抗尿调节蛋白单抗
| 名称
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Mouse Anti-Uromucoid Antibody
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| 中文名
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抗尿调节蛋白单抗
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| 基本描述
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This gene encodes uromodulin, the more abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq]
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| 抗体类型
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Monoclonal
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| 纯化方法
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affinity purified by Protein A or Protein G
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| 储 存 液
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0.01M PBS(pH7.4) with 1% BSA。
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| 存储条件
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Store at -20°C.
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| 亚型
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IgG
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