|
服务
产品  
|
Rabbit Anti-ACTH Antibody/促肾上腺皮质激素ACTH抗体
| 名称
|
Rabbit Anti-ACTH Antibody
|
| 中文名
|
促肾上腺皮质激素ACTH抗体
|
| 基本描述
|
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.
|
| 抗体类型
|
兔多抗
|
| 免疫原
|
偶联多肽或重组蛋白
|
| 浓度
|
1mg/ml
|
| 存储条件
|
Store at -20°C.
|
| 亚型
|
IgG
|
| 成分
|
亲和纯化，0.01M PBS(pH7.4)，1% BSA
|
| 应用
|
IH(P)免疫组化(石蜡、冰冻)；IC细胞免疫化学；WB免疫印迹等
|
|
