|
服务
产品  
|
Mouse vim/ Vimentin Protein/重组小鼠波形（VIM）蛋白
| 名称
|
Mouse vim/ Vimentin Protein/重组小鼠波形（VIM）蛋白
|
| 中文名
|
Mouse vim/ Vimentin Protein/重组小鼠波形（VIM）蛋白
|
| 基本描述
|
Vimentin, also know as VIM. It is the major subunit protein of the intermediate filaments of mesenchymal cells. It is believed to be involved with the intracellular transport of proteins between the nucleus and plasma membrane. Vimentin has been implicated to be involved in the rate of steroid synthesis via its role as a storage network for steroidogenic cholesterol containing lipid droplets. Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an ATP and myosin light chain dependent contractile event. This results in cytoskeletal changes that facilitate the interaction of the lipid droplets within mitochondria, and subsequent transport of cholesterol to the organelles to an increase in steroid synthesis. Immunohistochemical staining for Vimentin is characteristic of sarcomas (of neural, muscle and fibroblast origin) compared to carcinomas which are generally negative. Melanomas, lymphomas and vascular tumors may all stain for Vimentin. Vimentin antibodies are thus of value in the differential diagnosis of undifferentiated neoplasms and malignant tumors. They are generally used with a panel of other antibodies including those recognising cytokeratins, lymphoid markers, S100, desmin and neurofilaments.
|
| 分子别称
|
VIM，Vimentin
|
| 分子种属
|
Mouse
|
| 表达标签
|
His，S
|
| 表达宿主
|
E. coli
|
| 纯度
|
> 95 % as determined by SDS-PAGE
|
| 缓冲液
|
Lyophilized from sterile PBS, pH 7.4
|
| 保存方法
|
-70°C，应避免反复冻融。
|
|
