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服务
产品  
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Mouse gp130 / IL6ST / CD130 Protein/重组小鼠 gp130 / IL6ST / CD130 蛋白
| 名称
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Mouse gp130 / IL6ST / CD130 Protein/重组小鼠 gp130 / IL6ST / CD130 蛋白
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| 中文名
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Mouse gp130 / IL6ST / CD130 Protein/重组小鼠 gp130 / IL6ST / CD130 蛋白
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| 基本描述
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Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. CD130/gp130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). CD130/gp130 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD130/gp130 plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. CD130/gp130 binds to IL6/IL6R (alpha chain) complex, resulting in the formation of -affinity IL6 binding sites, and transduces the signal. CD130/gp130 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events.
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| 分子别称
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Ac1055, Gp130, Il-6rb
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| 分子种属
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Mouse
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| 表达标签
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His，S
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| 表达宿主
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E. coli
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| 纯度
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> 95 % as determined by SDS-PAGE
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| 缓冲液
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Lyophilized from sterile PBS, pH 7.4
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| 保存方法
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-70°C，应避免反复冻融。
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