| Name
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(Asn670,Leu671)-Amyloid b/A4 Protein Precursor770 (667-675)
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| Code
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[150234-52-9]
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| The alias
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(Asn670,Leu671)-Amyloid b/A4 Protein Precursor770 (667-675)
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| Sequence (single letter abbreviation)
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SEVNLDAEF
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| Sequence (three-letter abbreviation)
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H-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-OH (trifluoroacetate salt)
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| A basic description
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This peptide comprises a Cu2+-binding site. Binding of Cu2+ to the peptide induced oxidation of the cysteine and intermolecular dimerization of the peptide. The reduction of Cu2+ to Cu+ by Amyloid beta/A4 Protein Precursor may enhance the production of hydroxyl radicals which in turn may contribute to neurodegeneration in Alzheimer's disease.
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| solubility
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| The molecular weight
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1023.1
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| Chemical formula
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C44H66N10O18
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| The purity
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80%，90%，95%，98%，99%
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| Weight
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1mg,5mg,10mg,50mg,100mg,1g
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| Storage conditions
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Store at -20°C. Keep tightly closed. Store in a cool dry place.
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| Annotation
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| Documents
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| Figures
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| Reference
|
M. Citron et al., Nature, 360, 672 (1992)
M. Mullan et al., Nature Gen., 1, 345 (1992)
S.R. Sahasrabudhe et al., J. Biol. Chem., 268, 16699 (1993)
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| The C-terminal
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| The N-terminal
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| Chemical bridge
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