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产品  
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 Substance P, Free Acid
| 名称
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Substance P, Free Acid
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| 别名
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SPOH
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| 序列（单字母缩写）
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RPKPQQFFGLM
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| 序列（三字母缩写）
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{ARG}{PRO}{LYS}{PRO}{GLN}{GLN}{PHE}{PHE}{GLY}{LEU}{MET}
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| 基本描述
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The conformation of substance P (free acid) (SPOH) has been investigated in dimethylsulfoxide (DMSO), water and dipalmitoylphosphotidylcholine (DPPC) bilayers by two-dimensional NMR and restraint molecular dynamics simulations. The observed NOE patterns for substance P (free acid) in these media are very much different from each other. The conformation of substance P (free acid) in DPPC bilayers is characterized by gamma-bends at Pro4,Gln6and Phe7, which are stabilized by hydrogen bonding between Lys3CO-->Gln5NH, Gln5CO-->Phe7NH and Gln6CO-->Phe8NH, respectively. The absence of biological activity in SPOH has been attributed to the absence of any helix like structure at the central residues and absence of any interresidue interaction with C-terminal OH group, in DPPC bilayers, a feature shown to be an important prerequisite for SP and SP agonists to bind to the NKI tachykinin receptor.
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| 分子量
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1348.700
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| 化学式
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C63H97N17O14S1
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| 纯度
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> 95%
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| 存储条件
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Store at -20°C.
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| 注释
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